Offering 02 · Discovery & Pre-Clinical

De-risk discovery, before the clinic.

Assay development, compound screening, and disease-relevant profiling that ground drug discovery in real biology — turning targets and libraries into validated, de-risked starting points for development.

Hit→Lead
Validated Discovery Starting Points

"Discovery grounded in disease-relevant biology, ready to advance."

Overview

Where drug discovery begins — and gets de-risked

Great programmes are made or lost in the pre-clinical stage. We develop the assays, run the screens, and profile the hits that ground discovery in disease-relevant biology — so the compounds that advance are the ones most likely to succeed.

From target-based and phenotypic assays to complex disease models, our work turns libraries and targets into validated, prioritised starting points for the clinic.

At a glance

  • Assay development — optical, label-free, high-content imaging
  • Target- and cell-based compound screening
  • Disease-relevant models (2D / 3D, patient-derived, organoids)
  • Hit triage: mechanism, selectivity, and ADMET profiling
  • Hit-to-Lead and Candidate progression
  • Translational readiness to de-risk the clinic
Capabilities

What the Discovery & Pre-Clinical offering delivers

01

Assay Development

Miniaturized, target-based assays for major protein classes plus complex cell-based systems — optical, label-free, and high-content imaging (Cell-Painting).

Assays
02

Compound Screening

Screening against small molecule libraries or focused subsets — including natural-product and drug-repurposing collections — on high-throughput infrastructure.

Screening
03

Disease-Relevant Models

2D and 3D cultures, patient-derived cells, and organoids that ground discovery in the biology that matters for translation.

Translational
04

Hit Triage & Profiling

Prioritise hits by mechanism-of-action, selectivity, and ADMET profiling, supported by robust informatics.

Profiling
05

Hit-to-Lead & Candidate

Progress validated hits to industry-standard Lead and clinical Candidate milestones along a clear critical path.

Optimization
06

Clinical De-Risking

Early translational readiness — building the evidence that de-risks a compound before it reaches the clinic.

De-Risking
Scientific heritage

Proven at screening scale

Grounded in real drug-screening and compound-repurposing practice: target- and cell-based assays, access to compound libraries, high-content imaging, and integrated high-throughput screening hardware — with a track record across repurposing, rare disease, and oncology.

Small molecule libraries

Diverse screening compounds and repurposing collections

Biochemical assays

Target- and cell-based, disease-relevant assay systems

Lead → Candidate

Proven progression along drug-discovery critical paths

Better together

Discovery, connected and intelligent

Discovery data becomes far more powerful when it is digitised as FAIR data and reasoned over by the AI layer — turning every screen and assay into reusable, decision-ready knowledge.

See the AI offering →

Pairs with

Lab Digitisation — capture discovery data as structured, FAIR records.

AI — reason across screening data to predict and prioritise.

Bring us your target or phenotype

We'll design the assay, run the screen, and profile the hits — delivering validated, de-risked starting points for discovery.

Discuss a programme →